Key result
Low 18F-RGD uptake in the perfusion defect area 1 week after myocardial infarction significantly predicted an increase in left-ventricle end-diastolic volume at 12 weeks (r = 0.51, P < 0.05).
Why the study?
Does early (18)F-RGD PET imaging predict long-term left-ventricle remodeling after myocardial infarction in rats?
Population
Wistar rats undergoing permanent coronary ligation (n=25) or sham operation (n=9)
Comparison
F-galacto-RGD PET imaging 1 week after… vs Sham-operated controls
Design
Preclinical
Follow-up
12 weeks
Authors
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Hypothesis-generating for post-MI remodeling risk stratification; leaves open human validation before any clinical consideration.
Does early (18)F-RGD PET imaging predict long-term left-ventricle remodeling after myocardial infarction in rats?
Effect estimate: r = 0.51
p-value: p=< 0.05
Early molecular imaging of αvβ3 integrin expression using (18)F-RGD PET can predict long-term left ventricular remodeling after myocardial infarction in a rat model.
Sherif et al. (2012) studied Myocardial infarction (n=34). Myocardial 18F-RGD uptake vs. High 18F-RGD uptake was evaluated on Increase in left-ventricle end-diastolic volume (r = 0.51, p=< 0.05). Low 18F-RGD uptake in the perfusion defect area 1 week after myocardial infarction significantly predicted an increase in left-ventricle end-diastolic volume at 12 weeks (r = 0.51, P < 0.05).
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