May 2, 2010Journal of Biological ChemistryOpen Access

Site-specific Microtubule-associated Protein 4 Dephosphorylation Causes Microtubule Network Densification in Pressure Overload Cardiac Hypertrophy

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Population

Feline myocardium (normal, pressure overload-hypertrophied, and volume-overloaded) and normal cardiocytes

Comparison

Adenovirus-mediated expression of site-directed… vs Wild-type MAP4 expression and volume-overloaded…

Design

Preclinical

Authors

CPChinnakkannu PanneerselvamMedical University of South Carolina VSVenkatesababa SamannaMedical University of South Carolina GCGuangmao ChengBrown University

Discussion

Member takes

Implication

Suggests MAP4 dephosphorylation as a hypertrophy mechanism; leaves open translation to human disease or therapy.

Structured PICO

Population

Feline myocardium (normal, pressure overload-hypertrophied, and volume-overloaded) and normal cardiocytes

Intervention

Adenovirus-mediated expression of site-directed MAP4 mutants (Ser-924 --> Ala)

Comparator

Wild-type MAP4 expression and volume-overloaded myocardium

Outcome

Microtubule network density, stability, and MAP4 decorationsurrogate

Site-specific dephosphorylation of MAP4 at Ser-924 is a key mechanism driving microtubule network densification in pressure overload cardiac hypertrophy.

Cite This Study

Panneerselvam et al. (2010) studied this question.

synapsesocial.com/papers/6a7d1687f71d7d96a037cab3 https://doi.org/10.1074/jbc.m110.120709

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Site-specific Microtubule-associated Protein 4 Dephosphorylation Causes Microtubule Network Densification in Pressure Overload Cardiac Hypertrophy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Site-specific Microtubule-associated Protein 4 Dephosphorylation Causes Microtubule Network Densification in Pressure Overload Cardiac Hypertrophy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider