Key result
Overexpression of PP2A or PP1 in normal hearts reproduced the microtubule network densification and MAP4 dephosphorylation seen in maladaptive pressure overload cardiac hypertrophy.
Population
Preclinical models of maladaptive pressure overload cardiac hypertrophy and normal hearts
Comparison
Overexpression of PP2A or PP1 vs Normal hearts without overexpression
Design
Preclinical
Authors
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Implicates PP1/PP2A in hypertrophic microtubule remodeling; hypothesis-generating and should not yet change practice.
Increased activity of PP1 and PP2A in cardiac hypertrophy leads to MAP4 dephosphorylation and microtubule network densification, contributing to heart failure pathology.
Cheng et al. (2010) studied Pressure overload cardiac hypertrophy. Overexpression of PP2A or PP1 vs. Normal hearts was evaluated on Microtubule network phenotype and dephosphorylation of MAP4 Ser-924 and Ser-1056. Overexpression of PP2A or PP1 in normal hearts reproduced the microtubule network densification and MAP4 dephosphorylation seen in maladaptive pressure overload cardiac hypertrophy.
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