Why the study?
Although ventricular-arterial coupling and C-reactive protein are linked to the pathogenesis of heart failure, their relationship in patients at risk of heart failure remains unclear.
In hypertensive patients at risk for heart failure, higher levels of high-sensitivity C-reactive protein are independently associated with impaired ventricular-arterial coupling.
BACKGROUND: Although ventricular-arterial coupling (VAC) and C-reactive protein (CRP) are associated with the pathogenesis of heart failure (HF), their association in patients at risk of HF remains unclear. METHODS AND RESULTS: VAC was assessed by arterial elastance (Ea) to left ventricular endsystolic elastance (Ees) ratio (Ea/Ees) using the noninvasive single-beat method in 112 hypertensive patients. Log-transformed high-sensitivity CRP (hs-CRP) and categorical hs-CRP were associated with Ea/Ees on univariate analysis. Categorical hs-CRP was independently associated with Ea/Ees after adjusting for atherosclerotic risk factors, cardiac function and vascular function (β=0.27, P=0.003). CONCLUSIONS: hs-CRP was independently associated with VAC assessed by Ea/Ees in patients at risk of HF.
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Takei et al. (2026) studied this question.
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