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January 28, 2003The FASEB Journal

The prodomain of interleukin 1α interacts with elements of the RNA processing apparatus and induces apoptosis in malignant cells

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Why the study?

Does the IL-1alpha propiece induce apoptosis in malignant cells?

Population

Human tumor and primary human cell lines

Comparison

Expression of the 16 kDa IL-1alpha… vs Normal cell lines

Design

Preclinical

Authors

APAllan S. PollockSan Francisco VA Medical CenterJTJohanna TurckNorthern California Institute for Research and EducationDLDavid H. LovettAaron Diamond AIDS Research Center

Discussion

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Implication

Should not yet inform oncology practice; hypothesis-generating for RNA splicing-targeted apoptosis in malignancy.

Structured PICO

Does the IL-1alpha propiece induce apoptosis in malignant cells?

P
Population
Human tumor and primary human cell lines
I
Intervention
Expression of the 16 kDa IL-1alpha amino-terminal propiece
C
Comparator
Normal cell lines
O
Outcome
Induction of apoptosis and interaction with RNA processing apparatussurrogate

The IL-1alpha propiece induces apoptosis in tumor cells, likely through interaction with the RNA processing apparatus and alternate splicing of apoptosis regulatory proteins.

Cite This Study

Pollock et al. (2003) studied this question.

synapsesocial.com/papers/6a7d1690e9cd826fb346caf8https://doi.org/10.1096/fj.02-0602com
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