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March 12, 2014Neurology

Prehypertension increased the risk of stroke (RR 1.66; 95% CI 1.51-1.81) compared with optimal blood pressure (<120/80 mm Hg).

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Why the study?

Does prehypertension increase the risk of stroke compared to optimal blood pressure?

Population

762,393 participants from 19 prospective cohort studies

Comparison

Prehypertension vs Optimal blood pressure (<120/80 mm Hg)

Design

Meta-analysis

Authors

XCXiaoyan CaiAnhui Agricultural UniversityYLYingying LiShandong University of Traditional Chinese MedicineLSLiang SuChinese Academy of Medical Sciences & Peking Union Medical College

Discussion

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Member takes

Overview

Supports stroke risk stratification in prehypertension; confirms association and extends prior meta-analyses but requires RCTs before practice change.

Structured PICO

Does prehypertension increase the risk of stroke compared to optimal blood pressure?

P
Population
762,393 participants from 19 prospective cohort studies
I
Intervention
Prehypertension (including low-range: 120-129/80-84 mm Hg and high-range: 130-139/85-89 mm Hg)
C
Comparator
Optimal blood pressure (<120/80 mm Hg)
O
Outcome
Risk of strokehard clinical

Prehypertension, including both low-range and high-range categories, is significantly associated with an increased risk of stroke compared to optimal blood pressure.

Cite This Study

Cai et al. (2014) studied this question.

synapsesocial.com/papers/6a7d16fbd685fe2c2d7755c2https://doi.org/10.1212/wnl.0000000000000268
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