Why the study?
Do hyperandrogenic insulin-resistant women with PCOS display impaired endothelium-dependent vasodilation compared to healthy matched controls?
Population
25 women: 12 obese women with polycystic ovary syndrome and 13 healthy age- and weight-matched control…
Comparison
Graded intrafemoral artery infusions of the… vs Healthy age- and weight-matched control subjects.
Design
Case-control
Authors
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Endothelial dysfunction may contribute to CV risk in PCOS; supports hyperandrogenism link but leaves open causal role and therapeutic targets.
Do hyperandrogenic insulin-resistant women with PCOS display impaired endothelium-dependent vasodilation compared to healthy matched controls?
Women with PCOS exhibit endothelial dysfunction and resistance to insulin's vasodilating action, which strongly correlates with elevated free testosterone levels and may explain their increased macrovascular risk.
Paradisi et al. (2001) studied this question.
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