This review defines and discusses diabetic heart disease as myocardial disease in patients with diabetes that cannot be ascribed to hypertension or coronary artery disease.
May prompt consideration of diabetic cardiomyopathy in unexplained cases; leaves open validation of diagnostic criteria and targeted therapies.
Diabetes mellitus is responsible for a spectrum of cardiovascular disease. The best known complications arise from endothelial dysfunction, oxidation, inflammation, and vascular remodelling and contribute to atherogenesis. However, the effects on the heart also relate to concurrent hypertensive heart disease, as well as direct effects of diabetes on the myocardium. Diabetic heart disease, defined as myocardial disease in patients with diabetes that cannot be ascribed to hypertension, coronary artery disease, or other known cardiac disease, is reviewed.
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Thomas H. Marwick (2005) studied this question.
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