February 15, 2011Journal of Biological ChemistryOpen Access

Chronic Inhibition of Pyruvate Dehydrogenase in Heart Triggers an Adaptive Metabolic Response

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Population

Transgenic mice with cardiac-specific overexpression of pyruvate dehydrogenase kinase 4 (myosin heavy…

Design

Preclinical

Authors

KCKari T. ChambersUniversity of Oklahoma TLTeresa C. LeoneCardiovascular Institute of the South NSNandakumar SambandamSanford Burnham Prebys Medical Discovery Institute

Discussion

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Implication

Appears safe and protective in murine hearts; leaves open whether PDH inhibition benefits human cardiac ischemia or lipid overload.

Structured PICO

Population

Transgenic mice with cardiac-specific overexpression of pyruvate dehydrogenase kinase 4 (myosin heavy chain (MHC)-PDK4 mice)

Intervention

Cardiac-specific overexpression of pyruvate dehydrogenase kinase 4 (PDK4)

Outcome

Metabolic and functional consequences, including response to cardiac ischemia-reperfusion injury and high fat diet-induced myocyte lipid accumulationsurrogate

Chronic inhibition of pyruvate dehydrogenase in the heart triggers an adaptive metabolic response that increases fatty acid oxidation capacity and protects against lipid accumulation without deleterious functional consequences.

Cite This Study

Chambers et al. (2011) studied this question.

synapsesocial.com/papers/6a7d19b8a88f8d6a789fff4d https://doi.org/10.1074/jbc.m110.217349

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Chronic Inhibition of Pyruvate Dehydrogenase in Heart Triggers an Adaptive Metabolic Response

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Chronic Inhibition of Pyruvate Dehydrogenase in Heart Triggers an Adaptive Metabolic Response

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider