Why the study?
Can the immunoaffinity separation method be used to isolate and detect serum Lp-X and apoE-rich HDL?
Can the immunoaffinity separation method be used to isolate and detect serum Lp-X and apoE-rich HDL?
The immunoaffinity separation method provides a potential diagnostic marker for screening LpX or apoE-rich HDL by utilizing the RLP-cholesterol/RLP-TG ratio.
The immunoaffinity separation method was developed to isolate and detect VLDL and CM remnants as remnant lipoprotein (RLP), but it can also detect abnormal lipoproteins in RLP fraction such as LpX and apoE-rich HDL as a kind of false positive phenomenon. Because those abnormal, unbound lipoproteins to the immunoaffinity gel have no apoB100 and apoA1, those lipoproteins are fractionated as RLP. However, it has become an interesting diagnostic marker for screening of LpX or apoE-rich HDL. By using the RLP-cholesterol/ RLP-TG ratio of lipoprotein structure, extremely high ratio were found when compared to the conventional RLP ratio because of the lack of TG in those lipoproteins.
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Nakajima et al. (2015) studied this question.
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