Why the study?
Positively-charged amino acids drive voltage sensor movement in voltage-gated ion channels, but determining the displacements of voltage sensor gating charges has proven difficult.
This optical tracking approach reveals that voltage sensor gating charge motion involves distinct rotation and tilted translation for different residues during activation.
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qBBr tracking resolves R1/R2 displacements in Shaker; leaves open applicability to cardiac Kv gating or channelopathies.
Priest et al. (2021) studied this question.
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