Prognostic Value of Plasma Renin Activity in Renovascular Hypertension
Why the study?
Does measurement of suprarenal plasma renin activity predict surgical success in patients with unilateral renovascular hypertension?
Population
78 hypertensive patients with unilateral angiographic renovascular lesions
Comparison
Measurement of plasma renin activity from the… vs Measurement of plasma renin activity from…
Design
Cohort
Authors
Discussion
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Implication
Suprarenal renin sampling may aid prediction of surgical benefit in renovascular hypertension; hypothesis-generating and requires prospective validation before clinical adoption.
Key Points
- To evaluate the prognostic accuracy of plasma renin activity measured across various venous sites for predicting surgical outcomes in patients with renovascular hypertension.
- Analyzed 248 plasma samples collected from 78 hypertensive patients with unilateral angiographic renovascular lesions.
- Sampled venous blood from the humeral (brachial) vein, both renal veins, and the suprarenal and infrarenal inferior vena cava.
- Suprarenal inferior vena cava renin levels demonstrated an 87% prognostic accuracy in predicting postoperative surgical success.
- Peripheral vein renin levels correlated poorly with surgical benefit, and involved renal vein renin levels failed to consistently predict postoperative outcomes.
Structured PICO
Does measurement of suprarenal plasma renin activity predict surgical success in patients with unilateral renovascular hypertension?
P
Population
78 hypertensive patients with unilateral angiographic renovascular lesions
I
Intervention
Measurement of plasma renin activity from the suprarenal portion of the vena cava
C
Comparator
Measurement of plasma renin activity from peripheral veins or involved kidney veins
O
Outcome
Prediction of surgical success (postoperative benefit)surrogate
Suprarenal vena cava renin levels provide high prognostic accuracy for predicting surgical success in patients with unilateral renovascular hypertension.
Cite This Study
Meyer et al. (1967) studied this question.