Treatment of Malignant Disease With Nitrogen Mustard

Article1 May 1949TREATMENT OF MALIGNANT DISEASE WITH NITROGEN MUSTARDN. B. KURNICK, M.D., KARL R. PALEY, M.D., MACK H. FIEBER, M.D., D. K. ADLER, M.D.N. B. KURNICK, M.D.Search for more papers by this author, KARL R. PALEY, M.D.Search for more papers by this author, MACK H. FIEBER, M.D.Search for more papers by this author, D. K. ADLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-5-974 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOur purpose in this paper is to summarize the clinical literature on the use of the nitrogen mustards in malignant diseases,—the indications, hazards, effects and side-effects. Our experience with 64 additional cases is included.Reports on the clinical application of the nitrogen mustards in the treatment of neoplastic diseases have recently been released.1 Rhoads4 summarized the results of therapy as follows:1. Methyl-bis (β-chloroethyl) amine hydrochloride (designated HN2) appears to be preferable to tris (β-chloroethyl) amine hydrochloride as venous thrombosis is less likely to follow at the injection site.2. The recommended dosage is 0.1 mg. per kilogram intravenously on...Bibliography1. GILMANPHILIPS AFS: The biological actions and therapeutic applications of the β-chloroethyl amines and sulfides, Science, 1946, ciii, 409-415. CrossrefGoogle Scholar2. GOODMANWINTROBEDAMESHEKGOODMANGILMANMCLENNAN LSMMWMJAMT: Nitrogen mustard therapy, Jr. Am. Med. Assoc., 1946, cxxxii, 126-132. CrossrefGoogle Scholar3. JACOBSONSPURRBARRONSMITHLUSHBAUGHDICK LOCLESTCGF: Nitrogen mustard therapy: Studies on the effect of methyl-bis (beta-chloroethyl) amine hydrochloride on neoplastic diseases and allied disorders of the hemopoietic system, Jr. Am. Med. Assoc., 1946, cxxxii, 263-271. CrossrefGoogle Scholar4. RHOADS CP: Nitrogen mustards in the treatment of neoplastic disease, Jr. Am. Med. Assoc., 1946, cxxxi, 656-658. CrossrefGoogle Scholar5. SPURRJACOBSONSMITHGUZMAN BARRON CLLOTRES: The clinical application of a nitrogen mustard compound to the treatment of neoplastic disorders of the hemopoietic system, Cancer Res., 1947, vii, 51-52. Google Scholar6. ALPERTPETERSON LKSS: The use of nitrogen mustard in the treatment of lymphomata, Bull. U. S. Army Med. Dept., 1947, vii, 187-194. Google Scholar7. APTHOMASCULLUMBINE MIH: Nitrogen mustards in Hodgkin's disease, Lancet, 1947, cclii, 899-901. CrossrefGoogle Scholar8. WINTROBEHUGULEYMCLENNANDE C. LIMA MMCMMTLP: Nitrogen mustard as a therapeutic agent for Hodgkin's disease, lymphosarcoma, and leukemia, Ann. Int. Med., 1947, xxvii, 529-540. Google Scholar9. OSBORNEJORDANHOAKPSCHIERER EDJWFCPJ: Nitrogen mustard therapy in cutaneous blastomatous disease, Jr. Am. Med. Assoc., 1947, cxxxv, 1123-1128. CrossrefGoogle Scholar10. KIERLANDSHULLENBERGER RRCC: The use of nitrogen mustard in the treatment of mycosis fungoides, Jr. Invest. Dermat., 1947, ix, 195-202. CrossrefGoogle Scholar11. TAFFEL M: Experiences in the treatment of neoplastic diseases with nitrogen mustard, Yale Jr. Biol. and Med., 1947, xix, 971-978. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 4, 1948.This work was done in part under an American Cancer Society fellowship (N. B. Kurnick) recommended by the Committee on Growth of the National Research Council.From the Second Medical Service of the Mount Sinai Hospital, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Nitrogen MustardsTreatment of bronchogenic carcinomaDiseases of Medical ProgressComparative Therapeutic Activity of the Nitrogen Mustards and Allied CompoundsTherapy of the malignant lymphomasNITROGEN MUSTARD THERAPY COMPLICATED BY ACUTE RENAL FAILURE DUE TO URIC ACID CRYSTALLIZATION*GLENN H. RICHMOND, GRANT D. BEARDSLEYPresent status of clinical cancer chemotherapyDistribution of radioactivity in rats and man. After intravenous administration of diethyl β‐radioiodoethyl amine hydrochloride and of radioactive sodium iodide 1 May 1949Volume 30, Issue 5Page: 974-1003KeywordsFellowshipsMedical servicesThrombosis ePublished: 1 December 2008 Issue Published: 1 May 1949 PDF downloadLoading ...