What question did this study set out to answer?

To investigate whether the reduction in cardiac response and hemodynamic performance induced by beta-adrenergic receptor blockade affects patterns of urinary sodium excretion.

July 1, 1966Annals of Internal Medicine

The Effect of Beta Adrenergic Blockade on Patterns of Urinary Sodium Excretion

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Why the study?

Does beta adrenergic blockade affect patterns of urinary sodium excretion in normal subjects and patients with heart disease?

Population

Normal subjects and patients with heart disease

Design

Other

Authors

SEStephen E. EpsteinBroad Institute

Discussion

Member takes

Implication

Alerts to potential sodium handling changes with beta-blockade; extends cardio-renal physiology for targeted heart disease research.

Key Points

To investigate whether the reduction in cardiac response and hemodynamic performance induced by beta-adrenergic receptor blockade affects patterns of urinary sodium excretion.
Assessed urinary sodium excretion dynamics before and after pharmacological beta-adrenergic receptor blockade.
Evaluated physiological and renal responses across cohorts of normal healthy subjects and patients with diagnosed heart disease.
Beta-adrenergic receptor blockade alters renal sodium excretion patterns in conjunction with decreased cardiac output responses.
Impairment of circulatory and cardiac responses to metabolic demands directly influences renal fluid and electrolyte handling.

Structured PICO

Does beta adrenergic blockade affect patterns of urinary sodium excretion in normal subjects and patients with heart disease?

Population

Normal subjects and patients with heart disease

Intervention

Beta adrenergic blockade

Outcome

Patterns of urinary sodium excretionsurrogate

This early physiological study aimed to determine if the impairment of hemodynamic performance caused by beta-adrenergic blockade is associated with changes in patterns of urinary sodium excretion.

Cite This Study

Stephen E. Epstein (1966) studied this question.

synapsesocial.com/papers/6a7d2316166e996abdd5a361 https://doi.org/10.7326/0003-4819-65-1-20

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The Effect of Beta Adrenergic Blockade on Patterns of Urinary Sodium Excretion

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The Effect of Beta Adrenergic Blockade on Patterns of Urinary Sodium Excretion

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider