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September 1, 2002Congestive Heart FailureOpen Access

Beta‐Adrenergic Blockade 2002: A Pharmacologic Odyssey in Chronic Heart Failure

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Key result

Beta blockers are supported as a critical component of standard therapy for chronic heart failure with systolic left ventricular dysfunction based on major clinical trials.

Why the study?

Do beta blocking agents improve outcomes in heart failure populations with systolic left ventricular dysfunction?

Population

Heart failure populations with systolic left ventricular dysfunction

Design

Review

Authors

DHDenise D. HermannUniversity of California, San Diego

Discussion

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Overview

Supports beta-blocker use in systolic HF; leaves open optimal agent selection and dosing in contemporary populations.

Structured PICO

Do beta blocking agents improve outcomes in heart failure populations with systolic left ventricular dysfunction?

P
Population
Heart failure populations with systolic left ventricular dysfunction
I
Intervention
Beta blocking agents

This review highlights the paradigm shift and evidence supporting beta-blockers as a critical component of standard therapy for chronic heart failure with systolic dysfunction.

Cite This Study

Denise D. Hermann (2002) conducted a review in Chronic heart failure with systolic left ventricular dysfunction. Beta blockers was evaluated. Beta blockers are supported as a critical component of standard therapy for chronic heart failure with systolic left ventricular dysfunction based on major clinical trials.

synapsesocial.com/papers/6a15bfb4a2f71238514eb133https://doi.org/10.1111/j.1527-5299.2002.01157.x

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rationale for Treatment of Patients With Chronic Heart Failure With Adrenergic Blockade1995 · 81 citations
  2. 2β-Blockers in Congestive Heart Failure: A Bayesian Meta-Analysis2001 · 391 citations
  3. 3A Trial of the Beta-Blocker Bucindolol in Patients with Advanced Chronic Heart Failure2001 · 1,008 citations
  4. 4Double-Blind, Placebo-Controlled Study of the Effects of Carvedilol in Patients With Moderate to Severe Heart Failure1996 · 618 citations
  5. 5Adrenergic effects on the biology of the adult mammalian cardiocyte.1992 · 872 citations