Why the study?
Does AT1R blockade reduce renal injury in a rat model of type 2 cardiorenal syndrome?
Population
Rats with both unilateral nephrectomy and surgically induced myocardial infarction, corresponding to a model…
Comparison
Olmesartan medoxomil or spironolactone vs Control group, rats with MI alone, and rats with…
Design
Preclinical
Follow-up
34 weeks after MI surgery
Authors
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Supports ARB preference over spironolactone for renal protection in this model; leaves open translation to human type 2 cardiorenal syndrome.
Does AT1R blockade reduce renal injury in a rat model of type 2 cardiorenal syndrome?
AT1R blockade with olmesartan reduces proteinuria and renal inflammation in a rat model of type 2 cardiorenal syndrome, suggesting a therapeutic role for ARBs in this condition.
Homma et al. (2011) studied this question.
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