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January 18, 1993FEBS LettersOpen Access

Cloning of the rat heart Na+ ‐Ca2+ exchanger and its functional expression in HeLa cells

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Population

Rat heart lambda ZAP cDNA library and HeLa cells

Design

Preclinical

Authors

JKJudith KasirNational Institutes of HealthHRHannah RahamimoffCold Spring Harbor Laboratory

Discussion

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Implication

Enables in vitro NCX functional studies; leaves open clinical relevance to human cardiac disease.

Structured PICO

P
Population
Rat heart lambda ZAP cDNA library and HeLa cells
I
Intervention
Cloning and functional expression of the rat heart Na+-Ca2+ exchanger gene
O
Outcome
Functional expression and electrogenic properties of the cloned transporter

The study successfully cloned the rat heart Na+-Ca2+ exchanger and demonstrated its functional expression and electrogenic properties in vitro.

Cite This Study

Kasir et al. (1993) studied this question.

synapsesocial.com/papers/6a7d250f166e996abdd5a427https://doi.org/10.1016/0014-5793(93)81737-k
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