April 1, 2005The Journal of PhysiologyOpen Access

Sensory transduction of pulmonary reactive oxygen species by capsaicin‐sensitive vagal lung afferent fibres in rats

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Population

132 anaesthetized and ventilated rats (recording from 132 capsaicin-sensitive vagal lung afferent fibres)

Comparison

Airway challenge with aerosolized H2O2 or… vs Vehicle controls

Design

Preclinical

Authors

TRTing RuanFu Jen Catholic University YLYou Shuei LinTaipei Medical University KLKae‐Shin LinNational Yang Ming Chiao Tung University

Discussion

Member takes

Implication

Preclinical evidence implicates TRPV1/P2X in ROS sensing by vagal afferents; leaves open translation to human cardiopulmonary reflexes.

Structured PICO

Population

132 anaesthetized and ventilated rats (recording from 132 capsaicin-sensitive vagal lung afferent fibres)

Intervention

Airway challenge with aerosolized H2O2 (0.2% and 0.4%) or cigarette smoke (20 ml), with or without antagonists (capsazepine, iso-PPADS) or scavengers (dimethylthiourea, deferoxamine, catalase)

Comparator

Vehicle controls (vehicle for dimethylthiourea, iron-saturated deferoxamine, heat-inactivated catalase, and vehicles for receptor antagonists)

Outcome

Change in fibre activity (DeltaFA)surrogate

TRPV1 and P2X receptors mediate the sensory transduction of reactive oxygen species by capsaicin-sensitive vagal lung afferent fibres in rats.

Cite This Study

Ruan et al. (2005) studied this question.

synapsesocial.com/papers/6a7d2605e6f633beba6e4bfb https://doi.org/10.1113/jphysiol.2005.086181

View Full Paper

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Sensory transduction of pulmonary reactive oxygen species by capsaicin‐sensitive vagal lung afferent fibres in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sensory transduction of pulmonary reactive oxygen species by capsaicin‐sensitive vagal lung afferent fibres in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider