Why the study?
Does suppressing ATP and PCr availability compared to inhibiting pH recovery worsen action potential morphology during myocardial reperfusion in a cardiomyocyte model?
Population
Mathematical model of the cardiomyocyte simulating ischemia and reperfusion
Comparison
Suppression of ATP and phosphocreatine… vs Inhibition of extracellular pH recovery during…
Design
Preclinical
Authors
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Hypothesis-generating for ATP/PCr preservation to limit reperfusion arrhythmias; leaves open translation beyond this cardiomyocyte model.
Does suppressing ATP and PCr availability compared to inhibiting pH recovery worsen action potential morphology during myocardial reperfusion in a cardiomyocyte model?
In a mathematical model of ischemia-reperfusion, maintaining ATP and phosphocreatine availability was more effective than pH recovery at mitigating action potential changes that precipitate reentrant arrhythmias.
Roberts et al. (2012) studied this question.
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