Why the study?
Tafazzin deficiency causes mitochondrial dysfunction and excessive reactive oxygen/nitrogen species production, which may impair SERCA2a through tyrosine nitration.
Does tafazzin deficiency impair SERCA function and alter SERCA2a tyrosine nitration in mouse left ventricles?
Population
Young (3-5 months) and old (10-12 months) WT and TazKD male mice
Comparison
TazKD mice vs WT mice across young and old age groups
Design
Preclinical animal study
Authors
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Tafazzin deficiency may impair cardiac SERCA via nitration in mice; leaves open relevance to human cardiomyopathy.
Does tafazzin deficiency impair SERCA function and alter SERCA2a tyrosine nitration in mouse left ventricles?
Tafazzin deficiency in mice impairs maximal SERCA activity in the left ventricle, likely due to elevated ROS/RNS production and SERCA2a tyrosine nitration, despite adaptive changes in phospholamban.
Braun et al. (2019) studied this question.
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