Population
36 individuals including normal pregnant women, pregnant women with Type I diabetes in the third trimester…
Design
Cross-sectional
Authors
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May enhance maternal IGF bioavailability in late pregnancy; hypothesis-generating and requires prospective validation before clinical relevance.
Pregnancy induces specific proteases that modify IGFBPs without altering the size distribution of IGFs, potentially increasing IGF bioavailability to maternal tissues.
Davies et al. (1991) studied this question.
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