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May 1, 1994Journal of Clinical InvestigationOpen Access

In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells.

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Why the study?

Does increased IGFBP-3 proteolysis in pregnancy serum increase IGF availability and stimulate DNA synthesis in cultured cells?

Population

Cultured chick embryo fibroblasts exposed to serum pools from healthy adults and women during late pregnancy

Comparison

Pregnancy serum vs Normal serum from healthy adults

Design

Preclinical

Authors

CBC. BlatInsermJVJ. VillaudyCentre National de la Recherche ScientifiqueMBM BinouxInserm

Discussion

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Implication

Supports IGF bioavailability via IGFBP-3 proteolysis in pregnancy; hypothesis-generating for human cell-growth regulation.

Structured PICO

Does increased IGFBP-3 proteolysis in pregnancy serum increase IGF availability and stimulate DNA synthesis in cultured cells?

P
Population
Cultured chick embryo fibroblasts exposed to serum pools from healthy adults and women during late pregnancy
I
Intervention
Pregnancy serum (characterized by increased IGFBP-3 proteolysis)
C
Comparator
Normal serum from healthy adults
O
Outcome
DNA synthesis stimulationsurrogate

In vivo proteolysis of IGFBP-3, as seen in pregnancy serum, increases the bioavailability of IGFs to target cells, enhancing biological activity such as DNA synthesis.

Cite This Study

Blat et al. (1994) studied this question.

synapsesocial.com/papers/6a83f3dba91c8d236ee664e1https://doi.org/10.1172/jci117229
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Insulin-like growth factor-binding protein-3 is functionally normal in pregnancy serum.1992 · 73 citations
  2. 2Insulin-Like Growth Factor Binding Proteins in Maternal Serum Throughout Gestation and in the Puerperium: Effects of a Pregnancy-Associated Serum Protease Activity*1990 · 367 citations
  3. 3Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.1989 · 908 citations
  4. 4Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma.1986 · 522 citations
  5. 5Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules1989 · 594 citations