Why the study?
Patients with CKD experience accelerated vascular aging and CVD risk despite pharmacological therapy, while adherence to protective aerobic exercise is limited by numerous barriers.
Does high-resistance inspiratory muscle strength training (IMST) improve vascular health and reduce cardiovascular disease in patients with chronic kidney disease?
Does high-resistance inspiratory muscle strength training (IMST) improve vascular health and reduce cardiovascular disease in patients with chronic kidney disease?
High-resistance inspiratory muscle strength training is proposed as a novel, feasible non-pharmacological strategy to improve vascular health in patients with chronic kidney disease.
May support aerobic exercise for vascular health in CKD; hypothesis-generating and requires RCTs before practice change.
Patients with chronic kidney disease (CKD) demonstrate accelerated vascular aging which contributes to an increased risk of cardiovascular disease (CVD). Impaired vascular health in CKD is characterized by both functional and structural alterations to the vasculature including hypertension, arterial stiffness, vascular endothelial dysfunction, and autonomic dysfunction. These detriments persist despite pharmacological intervention. Habitual aerobic exercise can be protective of vascular health; however, the feasibility in patients with CKD is low due to numerous barriers to exercise. In this perspective we emphasize the need for novel and non-pharmacological strategies that can rescue vascular health and reduce the development of CVD in patients with CKD, explain the unique barriers to aerobic exercise in CKD, present a novel physical training intervention-high-resistance inspiratory muscle strength training (IMST) that addresses the barriers to exercise, and provide our opinion on why this lifestyle intervention may be particularly efficacious for patients with CKD.
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Lapierre-Nguyen et al. (2025) studied this question.
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