Evaluation of cytotoxicity potential of Garcinia cambogia (Gaertn.) Desr. male flower extract using Allium cepa model

The cytotoxic and genotoxic effects of various solvent extracts of male flower was carried out Garcinia cambogia using model.The solvents such as distilled water, ammonia, ethyl acetate and hexane were used for Allium cepa extraction.The percent mitotic index of all extracts decreased with increase in extract concentrations.A dose dependent decrease in root length with an increase in the extract concentration was also observed.The results revealed aberrations such as chromosome bridge, nuclear lesions, vagrant chromosomes, c-metaphase, abnormal separation and disturbed metaphase.Hence it can be concluded from the results that the plant extracts are cytotoxic and genotoxic in nature.