Antiulcerogenic activities of Heterotis rotundifolia (Sm.) Jacq. Fel extract and fractions and their phytochemical constituents

Objective:used traditionally by the Ibibio people of Southern Nigeria for the Heterotis rotundifolia (Sm.)Jacq.Fel treatment of pain, stomach ulcer, malaria and other inflammatory diseases .was evaluated for antiulcer activity Materials and Methods: In this study, the effects of the extract (300-900 mg/kg) and different fractions [n-hexane (HEX), ethyl acetate (EAC), methanol (MET) and aqueous (AQU), 600 mg/kg) on experimentally induced ulcer were studied in rats using ethanol, indomethacin and histamine -induced ulcer models.: 300-900 Results The extract ( mg/kg) inhibited ethanol, indomethacin and histamine -induced ulcer models in a dose dependent fashion.The various degrees of inhibitions were statistically significant (p<0.05,0.01, 0.001).The effect of the extract and the different fractions were comparable to that of the standard drugs the MET fraction having the highest activity used, .GC-MS analysis of the MET extract revealed the of presence polyunsaturated fatty acids such as tridecanoic acid-12methyl ester, -5,8,11,14,17-Eicosapentaenoic acid, octadecanoic acid methyl ester, tetracosanoic acid, 9,12-cis Octadecadienoic acid (Z,Z)-, and hexadecanoic acid ethyl ester.: Conclusion Thus, demonstrated a H. rotundifolia good antiulcer activity which supports the use of this plant among the Ibibio people of Southern Nigeria ethnopharmacology for ulcer treatment.