Why the study?
Current therapeutics cannot eliminate ischemia-induced cardiomyocyte loss after myocardial infarction, making the mechanisms of cardiomyocyte proliferation, metabolic reprogramming, and cardiac regeneration critical areas of investigation.
Does DHA supplementation or metabolic reprogramming promote cardiomyocyte proliferation and cardiac regeneration after myocardial infarction?
Population
Preclinical models (adult zebrafish, neonatal mice, and adult mice) of myocardial infarction and heart injury
Design
Review
Authors
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Supports potential adult CM regeneration post-MI; hypothesis-generating and requires validation before clinical consideration.
Does DHA supplementation or metabolic reprogramming promote cardiomyocyte proliferation and cardiac regeneration after myocardial infarction?
DHA supplementation and metabolic reprogramming via fatty acid oxidation modulation show promise in promoting cardiomyocyte proliferation and cardiac regeneration in preclinical models of myocardial infarction.
Jing‐Wei Xiong (2025) studied this question.
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