Key result
Stimulation of glycolysis via PDK3 overexpression promoted cardiomyocyte dedifferentiation and proliferation following cardiac injury in adult zebrafish and mammalian cardiomyocytes.
Why the study?
The role of cardiac metabolism in different aspects of cardiomyocyte regeneration remains unclear.
Population
Adult zebrafish heart regeneration model and cultured mammalian cardiomyocytes
Comparison
Loss- and gain-of-function manipulations of metabolic regulators versus controls
Authors
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Hypothesis-generating for PDK3-driven cardiomyocyte regeneration; leaves open translation to human cardiac repair.
Stimulation of glycolysis and modulation of the PDK-PDC axis promote cardiomyocyte dedifferentiation and proliferation following cardiac injury in zebrafish and mammalian models.
Fukuda et al. (2020) studied Cardiac injury. Stimulation of glycolysis (Pdk3 overexpression) vs. Control was evaluated on Cardiomyocyte proliferation. Stimulation of glycolysis via PDK3 overexpression promoted cardiomyocyte dedifferentiation and proliferation following cardiac injury in adult zebrafish and mammalian cardiomyocytes.
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