Why the study?
What is the frequency of and risk factors for intracranial hemorrhage after tPA treatment in patients with acute myocardial infarction?
Population
71,073 patients who had acute myocardial infarction from 1 June 1994 to 30 September 1996, received tPA as…
Design
Cohort
Follow-up
during hospitalization
Authors
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May guide monitoring in high-risk AMI patients receiving tPA; leaves open whether risk modification improves outcomes.
What is the frequency of and risk factors for intracranial hemorrhage after tPA treatment in patients with acute myocardial infarction?
Intracranial hemorrhage is a rare (0.88%) but highly fatal complication of tPA for acute myocardial infarction, with specific risk factors including older age, female sex, history of stroke, and tPA dose >1.5 mg/kg.
Jerry H. Gurwitz (1998) studied this question.
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