African Vegetables (Clerodendrum volubile Leaf and Irvingia gabonensis Seed Extracts) Effectively Mitigate Trastuzumab-Induced Cardiotoxicity in Wistar Rats

Figures

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  Figure 1. A cross-sectional representative of TZM intoxicated rat heart pretreated with 10 ml/kg/day of sterile water showing severe vascular congestion and intraparenchymal hemorrhage as well as coronary arterial wall thickening with endothelial microthrombi formation indicative of coronary arteriosclerosis (x400 magnification, hematoxylin-eosin stain).

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  Figure 2. A cross-sectional representative of the normal rat heart showing normal cardiac histoarchitecture (x400 magnification, hematoxylin-eosin stain).

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  Figure 3. A cross-sectional representative of the 400 mg/kg/day of CVE treated-rat heart showing normal cardiac histoarchitecture with mild pericardiac fat deposit (x400 magnification, hematoxylin-eosin stain).

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  Figure 4. A cross-sectional representative of the 400 mg/kg/day of IGE treated-rat heart showing normal cardiac histoarchitecture (x400 magnification, hematoxylin-eosin stain).

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  Figure 5. A photomicrograph of cross-sectional representative of TZM intoxicated rat heart orally pretreated with 20 mg/kg/day of vit. C showing mild vascular congestion, mild intraparenchymal hemorrhage, and increased pericardial fat thickness (x400 magnification, hematoxylin-eosin stain).

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  Figure 6. A photomicrograph of cross-sectional representative of TZM intoxicated rat heart treated with 400 mg/kg/day of CVE showing mild intraparenchymal hemorrhage with thickened coronary arterial wall suggestive of coronary arteriosclerosis (x400 magnification, hematoxylin-eosin stain).

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  Figure 7. A photomicrograph of cross-sectional representative of TZM intoxicated rat heart treated with 400 mg/kg/day IGE showing mild vascular congestion and coronary artery recanalization (x100 magnification, hematoxylin-eosin stain).