Why the study?
Sex-related threshold levels of high-sensitivity cardiac troponin assays have been proposed, prompting evaluation of the diagnostic and prognostic implications of adopting sex-specific thresholds in suspected acute coronary syndrome.
Does adopting sex-specific threshold troponin values impact diagnostic and prognostic evaluation in patients with a suspected acute coronary syndrome?
Does adopting sex-specific threshold troponin values impact diagnostic and prognostic evaluation in patients with a suspected acute coronary syndrome?
This review highlights the diagnostic and prognostic implications of adopting sex-specific threshold values for high-sensitivity cardiac troponin assays in the evaluation of suspected acute coronary syndrome.
Answers are grounded in this paper and cite their sources.
Sex-specific hs-cTn thresholds may refine acute injury diagnosis in women; leaves open prospective outcome validation before practice change.
: Advances in technology have led to an improvement in the ability to detect and quantify acute cardiomyocyte injury with the measurement of high-sensitivity cardiac troponin as compared with conventional assays. The upper reference limit for the high-sensitivity cardiac troponin assays is defined as the 99th percentile cutoff value in a healthy reference population. Since sex-related threshold levels of high-sensitivity cardiac troponin assays have been proposed, this review will focus on the diagnostic and prognostic implications of adopting sex-specific threshold troponin values in patients with a suspected acute coronary syndrome.
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Rocco et al. (2019) studied this question.
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