Key result
Using sex-specific cut-offs for high sensitivity cardiac troponin I minimally changed the proportion of patients with elevations (9.15% vs 9.29%) with no significant net gain in classification.
Why the study?
Do sex-specific cut-offs for high sensitivity cardiac troponin I improve prognostic identification and diagnostic classification in patients with suspected acute coronary syndrome compared to an overall cut-off?
Population
2841 patients with suspected acute coronary syndrome
Comparison
Sex-specific cut-offs for high sensitivity… vs Overall 99th centile value of a healthy…
Design
Editorial
Follow-up
1 year
Authors
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Sex-specific troponin cut-offs improve prognostic identification in women but do not significantly improve overall diagnostic classification for suspected ACS.
Do sex-specific cut-offs for high sensitivity cardiac troponin I improve prognostic identification and diagnostic classification in patients with suspected acute coronary syndrome compared to an overall cut-off?
Effect estimate: NRI -1.5%
Absolute Event Rate: 9.15% vs 9.29%
Sex-specific troponin cut-offs improve prognostic identification in women but do not significantly improve overall diagnostic classification for suspected ACS.
Evangelos Giannitsis (2016) conducted an editorial in suspected acute coronary syndrome (ACS) (n=2,841). Sex-specific cut-offs for high sensitivity cardiac troponin I vs. Overall 99th centile value (26 ng/L) was evaluated on Diagnostic classification of suspected acute coronary syndrome (NRI -1.5%). Using sex-specific cut-offs for high sensitivity cardiac troponin I minimally changed the proportion of patients with elevations (9.15% vs 9.29%) with no significant net gain in classification.
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