Why the study?
Does proton (1H) and phosphorus-31 (31P) MR spectroscopy accurately indicate completed cerebral infarction in a rat model?
Population
Rats with an experimental chronic cerebral infarction model
Comparison
Serial proton and phosphorus-31 magnetic… vs Reperfused recovered brain
Design
Preclinical
Follow-up
24 hours
Authors
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May mark completed infarction in rat models; leaves open translation to clinical stroke imaging.
Does proton (1H) and phosphorus-31 (31P) MR spectroscopy accurately indicate completed cerebral infarction in a rat model?
Proton MR spectroscopy showing persistent high lactate levels is a sensitive indicator of completed cerebral infarction, outperforming 31P spectroscopy.
Houkin et al. (1990) studied this question.