Population
Rats with experimentally induced brain infarction
Design
Preclinical
Follow-up
chronic phase (at least 48 hours)
Authors
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Rebound alkalosis with persistent lactate may confound subacute stroke pH imaging; hypothesis-generating in animals, human relevance untested.
In a rat model of brain infarction, a transient 'rebound alkalosis' occurs in the subacute phase alongside persistent lactate that was produced during the acute phase.
Nakada et al. (1991) studied this question.
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