Population
Long-Evans hooded rats (extensor digitorum longus [EDL] and soleus [SOL] muscles)
Comparison
Denervation (0 to 50 days) vs Baseline (0 days)
Design
Preclinical
Follow-up
up to 50 days
Authors
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Indicates fiber-type specificity in rodent denervation responses; leaves open translation to human neuromuscular disease.
Denervation induces muscle- and fiber-type specific structural and functional changes, indicating that intrinsic muscle fiber properties influence cellular responses to denervation.
Patterson et al. (2006) studied this question.
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