Key result
Denervation of murine fast-twitch muscle resulted in the differential expression of 71 genes, including downregulation of energy metabolism genes and a shift toward slow-fiber gene expression.
Why the study?
Does denervation alter gene expression and physiological properties in murine fast-twitch muscle?
Population
Adult (3-month old) CD1 mice (n=32)
Comparison
Unilateral sciatic nerve cut at the level of the… vs Contralateral innervated muscles
Design
Preclinical
Follow-up
1, 3, 7, and 14 days
Authors
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Should not yet inform clinical denervation management; leaves open mechanistic hypotheses for translational muscle research.
Does denervation alter gene expression and physiological properties in murine fast-twitch muscle?
Denervation in murine fast-twitch muscle induces rapid atrophy, downregulation of energy metabolism genes, and a shift from fast to slow fiber gene expression profiles.
Raffaello et al. (2005) studied Muscle denervation atrophy (n=32). Sciatic nerve denervation vs. Contralateral innervated muscle was evaluated on Differential gene expression in tibialis anterior muscle. Denervation of murine fast-twitch muscle resulted in the differential expression of 71 genes, including downregulation of energy metabolism genes and a shift toward slow-fiber gene expression.
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