Population
In situ preparations of rostral ventrolateral medulla presympathetic neurons from normal rats and rats…
Comparison
Chronic intermittent hypoxia (CIH) vs Normal rats (normoxia)
Design
Preclinical
Authors
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May inform mechanisms of sympathetic hyperactivity in CIH models; leaves open translation to human sleep apnea hypertension.
Chronic intermittent hypoxia enhances excitatory synaptic inputs to specific non-C1 respiratory-modulated RVLM presympathetic neurons, which may contribute to the increased sympathetic activity observed in this condition.
Moraes et al. (2013) studied this question.
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