January 1, 1995Clinical and Experimental Hypertension

Criteria for Intracellular Identification of Pre-Sympathetic Neurons in the Rostral Ventrolateral Medulla in the Rat

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Population

Anaesthetised rats

Design

Preclinical

Authors

JLJanusz LipskiUniversité Libre de Bruxelles RKRefik KanjhanThe University of Queensland BKBarbara KruszewskaUniversity of Rochester Medical Center

Discussion

Member takes

Implication

Animal data on RVLM criteria and AV3V-insulin sympathoexcitation are hypothesis-generating; human validation required before any clinical consideration.

Structured PICO

Population

Anaesthetised rats (intracellular recordings from 8 rostral ventrolateral medulla [RVLM] pre-sympathetic neurons)

Intervention

Intracellular recording, stimulation of the aortic depressor nerve, antidromic stimulation from upper thoracic segments, central/systemic administration of insulin, and anteroventral third ventricle hypothalamic (AV3V) lesions

Outcome

Criteria for intracellular identification of RVLM pre-sympathetic neuronssurrogate

This study establishes electrophysiological criteria for identifying pre-sympathetic RVLM neurons in vivo and highlights the role of AV3V-related structures in insulin-induced sympathetic outflow.

Cite This Study

Lipski et al. (1995) studied this question.

synapsesocial.com/papers/6a8544eaf2bb7ee68cf24095 https://doi.org/10.3109/10641969509087054

View Full Paper

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Implication

Animal data on RVLM criteria and AV3V-insulin sympathoexcitation are hypothesis-generating; human validation required before any clinical consideration.

Criteria for Intracellular Identification of Pre-Sympathetic Neurons in the Rostral Ventrolateral Medulla in the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Criteria for Intracellular Identification of Pre-Sympathetic Neurons in the Rostral Ventrolateral Medulla in the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider