Why the study?
Is endothelial function and arterial distensibility impaired in patients with well-controlled non-insulin dependent diabetes compared to matched healthy controls?
Is endothelial function and arterial distensibility impaired in patients with well-controlled non-insulin dependent diabetes compared to matched healthy controls?
This study investigates whether flow-mediated vasodilatation and arterial distensibility are altered as early markers of vascular dysfunction in non-insulin dependent diabetes.
Vascular testing in well-controlled diabetes remains investigational; hypothesis-generating for early dysfunction markers pending prospective data.
Atheroma is the main cause of mortality and morbidity in patients with non-insulin dependent diabetes mellitus. Endothelial dysfunction underlies atheroma formation. Flow mediated vasodilatation is a measure of endothelial function as well as a determinant of arterial distensibility,1 measurements of which have not previously been reported in patients with non-insulin dependent diabetes. We studied 12 symptom free, non-smoking, healthy patients (six men) with well controlled non-insulin dependent diabetes diabnosed 1-7 (mean 3.8) years previously (mean age 50 (SD 9) years, body mass index 26.9 (4.8) kg/m2, serum cholesterol concentration 5.8 (0.5) mmol/l). Patients with known causes of endothelial dysfunction were excluded. All patients had insulin resistance with basal hyperinsulinaemia,2 no biochemical evidence of renal impairment, and no microalbuminuria. A group of 12 normal non-smoking subjects was matched for sex, age, body mass index, blood …
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Goodfellow et al. (1996) studied this question.
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