April 14, 2000Circulation Research
Enhanced Cardiac Function in Transgenic Mice Expressing a Ca 2+ -Stimulated Adenylyl Cyclase
Why the study?
Does transgenic overexpression of Ca(2+)-stimulatable adenylyl cyclase type 8 (AC8) in the heart alter cardiac function in mice?
Population
Transgenic mice expressing the Ca(2+)-stimulatable adenylyl cyclase type 8 (AC8) specifically in the heart
Comparison
Transgenic overexpression of Ca-stimulatable… vs Non-transgenic controls
Design
Preclinical
Authors
Discussion
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Implication
No immediate clinical implications; leaves open AC8 transgenic mice as a model to probe Ca2+-cAMP effects on contractility.
Structured PICO
Does transgenic overexpression of Ca(2+)-stimulatable adenylyl cyclase type 8 (AC8) in the heart alter cardiac function in mice?
P
Population
Transgenic mice expressing the Ca(2+)-stimulatable adenylyl cyclase type 8 (AC8) specifically in the heart
I
Intervention
Transgenic overexpression of Ca(2+)-stimulatable adenylyl cyclase type 8 (AC8) specifically in the heart
C
Comparator
Non-transgenic controls (implied by comparison to endogenous activity)
O
Outcome
Cardiac function including heart rate, contractile function, adenylyl cyclase activity, and protein kinase A activitysurrogate
Transgenic mice expressing AC8 in the heart demonstrate enhanced intrinsic contractility, providing a novel model to investigate the relative influence of Ca2+ and cAMP on cardiac function.
Cite This Study
Lipskaia et al. (2000) studied this question.