Why the study?
Does deficiency or blockade of alpha1H T-type Ca2+ channels impair coronary artery relaxation in mice?
Population
Mice deficient in the alpha1H T-type Ca2+ channel (alpha(1)3.2-null) and wild-type mice
Comparison
Genetic knockout of alpha1H T-type Ca2+ channel… vs Wild-type mice / unblocked wild-type coronary…
Design
Preclinical
Authors
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T-type Ca channel loss impairs coronary relaxation in mice; leaves open relevance to human vasomotor dysfunction.
Does deficiency or blockade of alpha1H T-type Ca2+ channels impair coronary artery relaxation in mice?
Ca2+ influx through alpha1H T-type Ca2+ channels is essential for normal relaxation of coronary arteries in mice.
Chen et al. (2003) studied this question.
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