Key result
CaV 3.1 T-type Ca2+ channels are essential for maintaining myogenic tone at low arterial pressures (40-80 mm Hg) in mouse mesenteric arteries and arterioles.
CaV 3.1 T-type calcium channels play a key role in regulating arteriolar myogenic tone at low arterial pressures, and the putative blocker NNC 55-0396 lacks specificity.
No takes yet. Share an insight, caveat, or question.
Implicates CaV3.1 in low-pressure myogenic tone in mice; leaves open human translation and selective targeting.
Björling et al. (2013) studied this question. CaV 3.1 T-type Ca2+ channel deficiency vs. Wild-type mice was evaluated on Myogenic tone at low pressures (40-80 mm Hg). CaV 3.1 T-type Ca2+ channels are essential for maintaining myogenic tone at low arterial pressures (40-80 mm Hg) in mouse mesenteric arteries and arterioles.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: