Key result
L- and T-type Ca2+ channels are expressed in rat cerebral arterial smooth muscle and both contribute to myogenic tone, with L-type dominating at higher pressures and T-type at lower pressures.
Why the study?
Does inhibition of L- and T-type Ca2+ channels alter myogenic tone in rat cerebral arteries?
Does inhibition of L- and T-type Ca2+ channels alter myogenic tone in rat cerebral arteries?
Both L- and T-type Ca2+ channels are expressed in rat cerebral arterial smooth muscle and contribute to myogenic tone, with L-type dominating at high pressures and T-type at low pressures.
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Hypothesis-generating for pressure-dependent Ca2+ channel roles in cerebral myogenic tone; leaves open translation to human autoregulation or therapy.
El-Rahman et al. (2012) studied Myogenic tone in cerebral arteries. L-type and T-type Ca2+ channel blockers (nifedipine, mibefradil, kurtoxin, efonidipine) vs. Control conditions was evaluated on Myogenic tone and whole-cell Ba2+ currents. L- and T-type Ca2+ channels are expressed in rat cerebral arterial smooth muscle and both contribute to myogenic tone, with L-type dominating at higher pressures and T-type at lower pressures.
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