Why the study?
Does combined L- and T-channel blockade improve inhibition of vascular contractile responses compared to L-channel blockade alone in microvessels?
Does combined L- and T-channel blockade improve inhibition of vascular contractile responses compared to L-channel blockade alone in microvessels?
T-type calcium channels play an important role in regulating contractile responses in the microvasculature, suggesting they are a potential therapeutic target for microvascular disorders.
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Hypothesis-generating for dual L/T-channel blockade in microvascular dysfunction; leaves open any role in human disease.
Ball et al. (2009) studied this question.
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