Key result
Positive PKA modulators suppressed T-type Ca2+ currents and evoked a hyperpolarized shift in steady-state inactivation, specifically targeting the CaV3.2 subtype in rat cerebral arteries.
Population
Rat cerebral arterial smooth muscle cells
Comparison
Positive PKA modulators and PKA blockers vs Basal conditions
Design
Preclinical
Authors
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May support PKA-driven cerebral vasodilation via CaV3.2; leaves open translation to human disease or therapy.
PKA-mediated vasodilatory signaling cascades inhibit T-type Ca2+ channel conductance by specifically targeting the CaV3.2 subtype in rat cerebral arterial smooth muscle.
Harraz et al. (2013) studied this question. Protein kinase A (PKA) modulators was evaluated on T-type Ca2+ channel conductance. Positive PKA modulators suppressed T-type Ca2+ currents and evoked a hyperpolarized shift in steady-state inactivation, specifically targeting the CaV3.2 subtype in rat cerebral arteries.
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