Systematic Reviews and Meta-analyses of the Procedure-specific Risks of Thrombosis and Bleeding in General Abdominal, Colorectal, Upper Gastrointestinal, and Hepatopancreatobiliary Surgery
Why the study?
Pharmacological thromboprophylaxis involves a trade-off depending on VTE and bleeding risks that vary across abdominal procedures, but the magnitude of these risks remained uncertain.
What are the procedure-specific risks of symptomatic venous thromboembolism and major bleeding after abdominal surgery to guide pharmacological thromboprophylaxis?
Population
8,048,635 patients across 285 studies undergoing abdominal surgery
Comparison
Procedure-specific risks of symptomatic VTE vs major bleeding
Design
Systematic review and meta-analysis of observational studies
Follow-up
4 weeks postsurgery
Authors
Discussion
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Member takes
Implication
Procedure-specific VTE and bleeding risks may guide individualized prophylaxis; leaves open practice change pending randomized validation.
Structured PICO
What are the procedure-specific risks of symptomatic venous thromboembolism and major bleeding after abdominal surgery to guide pharmacological thromboprophylaxis?
P
Population
8,048,635 patients from 285 observational studies undergoing general abdominal, colorectal, upper gastrointestinal, and hepatopancreatobiliary surgery
I
Intervention
Pharmacological thromboprophylaxis
O
Outcome
Cumulative incidence of symptomatic venous thromboembolism (VTE) and major bleeding at 4 weeks postsurgeryhard clinical
VTE and bleeding risks vary substantially by specific abdominal surgery procedure, necessitating individualized decisions for pharmacological thromboprophylaxis.
Limitations
- Evidence certainty generally moderate or low for VTE
- Evidence certainty low or very low for bleeding requiring reintervention
Cite This Study
Lavikainen et al. (2023) studied this question.