Why the study?
Does dysferlin deficiency increase susceptibility to coxsackievirus-induced myocardial damage in mice?
Population
Naturally occurring and genetically engineered dysferlin-deficient mice
Design
Preclinical
Authors
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Dysferlin deficiency may heighten coxsackievirus myocarditis susceptibility in mice; hypothesis-generating for human host factors and needs clinical validation.
Does dysferlin deficiency increase susceptibility to coxsackievirus-induced myocardial damage in mice?
Dysferlin deficiency is a novel host risk factor for viral myocarditis, and its cleavage by viral proteinases represents a key mechanism for coxsackievirus-induced cardiac dysfunction.
Wang et al. (2015) studied this question.
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