Population
Isolated adult rat heart cells
Comparison
Hypoxia, re-oxygenation, and acidosis vs Aerobic controls supplemented with glucose
Design
Preclinical
Authors
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Hypothesis-generating for pH modulation in ischemia; should not change practice without in vivo confirmation.
Acidosis protects isolated rat heart cells from calcium-dependent contracture and respiratory loss during simulated ischemia and re-oxygenation.
Altschuld et al. (1981) studied this question.
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