Population
Mouse aortic endothelial cells (MAECs) isolated from wild-type and TRPV4(-/-) mice
Comparison
TRPV4-activating stimuli and modulators of the… vs Wild-type vs TRPV4 MAECs, and unmodulated vs…
Design
Preclinical
Authors
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These murine findings should not change practice; leaves open therapeutic targeting of endothelial TRPV4 via CYP2C/sEH in humans.
CYP-derived EETs modulate the activity of TRPV4 channels in endothelial cells, revealing novel modulatory pathways via CYP2C and sEH.
Vriens et al. (2005) studied this question.
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