Why the study?
Does isoproterenol induce differential left ventricular hypertrophy and beta-adrenergic receptor responses in A/J versus C57BL/6J mice?
Does isoproterenol induce differential left ventricular hypertrophy and beta-adrenergic receptor responses in A/J versus C57BL/6J mice?
High-dose isoproterenol produces greater cardiac hypertrophy and injury in A/J mice compared to B6 mice, likely due to differences in beta-adrenergic receptor downregulation.
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A/J strain differences in isoproterenol-induced LV hypertrophy support genetic models of beta-adrenergic remodeling; hypothesis-generating and requires validation before any clinical inference.
Faulx et al. (2005) studied this question.
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