April 4, 2014Frontiers in PhysiologyOpen Access

Cardiac looping may be driven by compressive loads resulting from unequal growth of the heart and pericardial cavity. Observations on a physical simulation model

View Full Paper

Ask AI

Bookmark

Population

Physical simulation model of the embryonic heart tube (straight elastic rod within a hemispherical cavity)

Comparison

Simulation of compressive loads resulting from… vs Bilaterally symmetric conditions versus…

Design

Preclinical

Authors

JMJörg MännerUniversity of Göttingen

Discussion

Member takes

Implication

Does not alter clinical practice; extends physical models of cardiac looping but remains hypothesis-generating.

Structured PICO

Population

Physical simulation model of the embryonic heart tube (straight elastic rod within a hemispherical cavity)

Intervention

Simulation of compressive loads resulting from unequal growth of the heart and pericardial cavity (growth-induced buckling)

Comparator

Bilaterally symmetric conditions versus asymmetric positioning of the caudal end

Outcome

Sequence of form changes (ventral bending, simple helical coiling, complex helical coiling) and generation of D- or L-loops

A physical simulation model demonstrates that compressive loads from unequal growth of the heart and pericardial cavity can drive the complex form changes of embryonic cardiac looping.

Cite This Study

Jörg Männer (2014) studied this question.

synapsesocial.com/papers/6a7d4daad3686d25b46e5535 https://doi.org/10.3389/fphys.2014.00112

View Full Paper

Ask AI

Bookmark

Cardiac looping may be driven by compressive loads resulting from unequal growth of the heart and pericardial cavity. Observations on a physical simulation model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac looping may be driven by compressive loads resulting from unequal growth of the heart and pericardial cavity. Observations on a physical simulation model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider